On October 11, 2024, the European Chemicals Agency (ECHA) added 17 new substance testing proposals, seeking public input by set deadlines. This is part of a transparent process to determine if additional tests are needed for registered chemicals.
Under REACH regulations, registrants are required to submit a Testing Proposal (TP) for volumes of 100-1000 tonnes/year and over 1000 tonnes/year, before advancing to Annexes IX and X. Following public consultation, ECHA will finalize testing requirements based on feedback and substance traits. This process enhances safety assessments and adjusts testing protocols. Registrants must conduct these tests and update their safety data, ensuring chemical safety and promoting sustainable practices.
| Name | EC Number | CAS Number |
Deadline for submitting information | Hazard endpoint for which vertebrate testing was proposed |
| (Z)-2-Butenedioic acid dipotassium salt | 637-001-6 | 4151-34-2 | 25/11/2024 | 7.6.2 Genetic toxicity in vivo |
| 1,1,1,3,5,5,5-heptamethyltrisiloxane | 217-496-1 | 1873-88-7 | 25/11/2024 | 5.3.1 Bioaccumulation aquatic / sediment |
| 2-methylprop-2-en-1-ol | 208-161-0 | 513-42-8 | 25/11/2024 |
6.1.2 Long-term toxicity to fish 7.5.1 Repeated dose toxicity: oral 7.8.1 Toxicity to reproduction 7.8.2 Developmental toxicity / teratogenicity |
| 3,5,5-trimethylhexanoic acid | 221-975-0 | 3302-10-1 | 25/11/2024 | 6.1.2 Long-term toxicity to fish |
| 5-amino-3-(trifluoromethyl)pyridine-2-carbonitrile | 815-137-9 | 573762-62-6 | 25/11/2024 | 7.6.2 Genetic toxicity in vivo |
| Dipotassium tartrate | 213-067-8 | 921-53-9 | 25/11/2024 |
6.1.2 Long-term toxicity to fish||Note: testing proposed with CAS no. 6381-59-5 7.8.1 Toxicity to reproduction||Note: testing proposed with CAS no. 6381-59-5 7.8.2 Developmental toxicity / teratogenicity||Note: testing proposed with CAS no. 6381-59-5 |
| Distillates (petroleum), cracked stripped steam-cracked petroleum distillates, C8-10 fraction EDPOINTS 7.8.1 | 270-728-3 | 68477-39-4 | 25/11/2024 |
7.8.1 Toxicity to reproduction||Note: testing proposed with Distillates (petroleum), cracked stripped steam-cracked petroleum distillates, C8-10 fraction (EC no. 270-728-3) 7.8.1 Toxicity to reproduction||Note: testing proposed with Extracts (petroleum), heavy naphtha solvent (EC no. 265-099-7) 7.8.1 Toxicity to reproduction||Note: testing proposed with Naphtha (petroleum), steam-cracked middle arom. (EC no. 271-138-9) 7.8.1 Toxicity to reproduction||Note: testing proposed with Solvent naphtha (petroleum), heavy arom. (EC no. 265-198-5) |
| Distillates (petroleum), cracked stripped steam-cracked petroleum distillates, C8-10 fraction ENDPOINTS 7.5.1 | 270-728-3 | 68477-39-4 | 25/11/2024 |
7.5.1 Repeated dose toxicity: oral||Note: testing proposed with Distillates (petroleum), cracked stripped steam-cracked petroleum distillates, C8-10 fraction (EC no. 270-728-3) 7.5.1 Repeated dose toxicity: oral||Note: testing proposed with Extracts (petroleum), heavy naphtha solvent (EC no. 265-099-7) 7.5.1 Repeated dose toxicity: oral||Note: testing proposed with Naphtha (petroleum), steam-cracked middle arom. (EC no. 271-138-9) 7.5.1 Repeated dose toxicity: oral||Note: testing proposed with Solvent naphtha (petroleum), heavy arom. (EC no. 265-198-5) |
| Distillates (petroleum), cracked stripped steam-cracked petroleum distillates, C8-10 fraction ENDPOINTS 7.8.2 | 270-728-3 | 68477-39-4 |
25/11/2024 |
7.8.2 Developmental toxicity / teratogenicity||Note: testing proposed with Distillates (petroleum), cracked stripped steam-cracked petroleum distillates, C8-10 fraction (EC no. 270-728-3) first species 7.8.2 Developmental toxicity / teratogenicity||Note: testing proposed with Distillates (petroleum), cracked stripped steam-cracked petroleum distillates, C8-10 fraction (EC no. 270-728-3) second species 7.8.2 Developmental toxicity / teratogenicity||Note: testing proposed with Extracts (petroleum), heavy naphtha solvent (EC no. 265-099-7) first species 7.8.2 Developmental toxicity / teratogenicity||Note: testing proposed with Extracts (petroleum), heavy naphtha solvent (EC no. 265-099-7) second species 7.8.2 Developmental toxicity / teratogenicity||Note: testing proposed with Naphtha (petroleum), steam-cracked middle arom. (EC no. 271-138-9) first species 7.8.2 Developmental toxicity / teratogenicity||Note: testing proposed with Naphtha (petroleum), steam-cracked middle arom. (EC no. 271-138-9) second species 7.8.2 Developmental toxicity / teratogenicity||Note: testing proposed with Solvent naphtha (petroleum), heavy arom. (EC no. 265-198-5) first species 7.8.2 Developmental toxicity / teratogenicity||Note: testing proposed with Solvent naphtha (petroleum), heavy arom. (EC no. 265-198-5) second species |
| Fatty acids, C14-18 and C16-18-unsatd., esters with propylene glycol | 284-864-6 | 84988-75-0 |
25/11/2024
|
7.5.1 Repeated dose toxicity: oral 7.8.2 Developmental toxicity / teratogenicity |
| Hydrochloric acid, reaction products with aniline and nitrobenzene, sulfonated, sodium salts | 291-454-0 | 90411-76-0 |
25/11/2024 |
6.1.2 Long-term toxicity to fish |
| Naphtha (petroleum), steam-cracked middle arom. ENDPOINTS 7.5.1 | 271-138-9 | 68516-20-1 |
25/11/2024 |
7.5.1 Repeated dose toxicity: oral||Note: testing proposed with Distillates (petroleum), cracked stripped steam-cracked petroleum distillates, C8-10 fraction (EC no. 270-728-3) 7.5.1 Repeated dose toxicity: oral||Note: testing proposed with Extracts (petroleum), heavy naphtha solvent (EC no. 265-099-7) 7.5.1 Repeated dose toxicity: oral||Note: testing proposed with Naphtha (petroleum), steam-cracked middle arom. (EC no. 271-138-9) 7.5.1 Repeated dose toxicity: oral||Note: testing proposed with Solvent naphtha (petroleum), heavy arom. (EC no. 265-198-5) |
| Naphtha (petroleum), steam-cracked middle arom. ENDPOINTS 7.8.1 | 271-138-9 | 68516-20-1 |
25/11/2024 |
7.8.1 Toxicity to reproduction||Note: testing proposed with Distillates (petroleum), cracked stripped steam-cracked petroleum distillates, C8-10 fraction (EC no. 270-728-3) 7.8.1 Toxicity to reproduction||Note: testing proposed with Extracts (petroleum), heavy naphtha solvent (EC no. 265-099-7) 7.8.1 Toxicity to reproduction||Note: testing proposed with Naphtha (petroleum), steam-cracked middle arom. (EC no. 271-138-9) 7.8.1 Toxicity to reproduction||Note: testing proposed with Solvent naphtha (petroleum), heavy arom. (EC no. 265-198-5) |
| Naphtha (petroleum), steam-cracked middle arom. ENDPOINTS 7.8.2 | 271-138-9 | 68516-20-1 |
25/11/2024 |
7.8.2 Developmental toxicity / teratogenicity||Note: testing proposed with Distillates (petroleum), cracked stripped steam-cracked petroleum distillates, C8-10 fraction (EC no. 270-728-3) first species 7.8.2 Developmental toxicity / teratogenicity||Note: testing proposed with Distillates (petroleum), cracked stripped steam-cracked petroleum distillates, C8-10 fraction (EC no. 270-728-3) second species 7.8.2 Developmental toxicity / teratogenicity||Note: testing proposed with Extracts (petroleum), heavy naphtha solvent (EC no. 265-099-7) second species 7.8.2 Developmental toxicity / teratogenicity||Note: testing proposed with Naphtha (petroleum), steam-cracked middle arom. (EC no. 271-138-9) first species 7.8.2 Developmental toxicity / teratogenicity||Note: testing proposed with Naphtha (petroleum), steam-cracked middle arom. (EC no. 271-138-9) second species 7.8.2 Developmental toxicity / teratogenicity||Note: testing proposed with Solvent naphtha (petroleum), heavy arom. (EC no. 265-198-5) first species 7.8.2 Developmental toxicity / teratogenicity||Note: testing proposed with Solvent naphtha (petroleum), heavy arom. (EC no. 265-198-5) second species |
| reaction product of toluenediisocyanate ( reaction mass of isomers: 65 % 2,4- and 35 % 2,6-diisocyanate) and aniline (molarratio 1:2) | 430-960-1 | - |
25/11/2024 |
7.6.2 Genetic toxicity in vivo||Note: testing proposed with Reaction mass of aniline and m-tolylidene diisocyanate (EC no. 901-891-7) |
| Solvent naphtha (petroleum), heavy arom. |
265-198-5 |
64742-94-5 |
25/11/2024 |
7.5.1 Repeated dose toxicity: oral||Note: testing proposed with Distillates (petroleum), cracked stripped steam-cracked petroleum distillates, C8-10 fraction (EC no. 270-728-3) 7.5.1 Repeated dose toxicity: oral||Note: testing proposed with Extracts (petroleum), heavy naphtha solvent (EC no. 265-099-7) 7.8.1 Toxicity to reproduction||Note: testing proposed with Distillates (petroleum), cracked stripped steam-cracked petroleum distillates, C8-10 fraction (EC no. 270-728-3) 7.8.1 Toxicity to reproduction||Note: testing proposed with Extracts (petroleum), heavy naphtha solvent (EC no. 265-099-7) 7.8.2 Developmental toxicity / teratogenicity||Note: testing proposed with Distillates (petroleum), cracked stripped steam-cracked petroleum distillates, C8-10 fraction (EC no. 270-728-3) first species 7.8.2 Developmental toxicity / teratogenicity||Note: testing proposed with Distillates (petroleum), cracked stripped steam-cracked petroleum distillates, C8-10 fraction (EC no. 270-728-3) second species 7.8.2 Developmental toxicity / teratogenicity||Note: testing proposed with Extracts (petroleum), heavy naphtha solvent (EC no. 265-099-7) second species |
| Trehalose |
202-739-6 |
99-20-7 |
25/11/2024 |
6.1.2 Long-term toxicity to fish |
