Under REACH regulations, registrants must develop a Testing Plan (TP) for substances produced in significant quantities, as detailed in Annexes IX and X. After public consultations, the European Chemicals Agency (ECHA) will adjust the testing requirements based on substance characteristics and stakeholder feedback.
On June 12, 2024, ECHA released 12 new testing proposals, inviting public comments by set deadlines.
| Name | EC Num./ CAS Num. | Hazard endpoint for which vertebrate testing was proposed | Deadline for submitting information |
| (8Z)-16-{[(2R,4S,5S)-6-[(acetyloxy)methyl]-3-{[(2S,4S,5S)-6-[(acetyloxy)methyl]-3,4,5-trihydroxyoxan-2-yl]oxy}-4,5-dihydroxyoxan-2-yl]oxy}heptadec-8-enoic acid; [(1S,4S,5S,8R,17Z,27S,31R)-28-[(acetyloxy)methyl]-4,5,30,31-tetrahydroxy-10-methyl-25-oxo-2,7,9,26,29-pentaoxatricyclo[25.2.2.0³,⁸]hentriacont-17-en-6-yl]methyl acetate |
941-809-7 - |
7.8.2 Developmental toxicity / teratogenicity | 29/07/2024 |
| 4,4'-Methylenedianiline, oligomeric reaction products with 1-chloro-2,3-epoxypropane |
500-062-3 28390-91-2 |
6.1.2 Long-term toxicity to fish||Note: testing proposed with 4,4'-methylenebis[N,N-bis(2,3-epoxypropyl)aniline] (EC no. 249-204-3) | 29/07/2024 |
| Menthol |
201-939-0 89-78-1 |
6.1.2 Long-term toxicity to fish | 28/06/2024 |
| N,N-dimethylacrylamide |
220-237-5 2680-03-7 |
7.8.2 Developmental toxicity / teratogenicity | 28/06/2024 |
| N-[3-(dimethylamino)propyl] C6-9 alkyl amides |
948-134-7 - |
6.1.2 Long-term toxicity to fish | 28/06/2024 |
| N-ethyldiethanolamine |
205-379-8 139-87-7 |
6.1.2 Long-term toxicity to fish 7.5.1 Repeated dose toxicity: oral 7.8.2 Developmental toxicity / teratogenicity |
29/07/2024 |
| Octanoic acid, monoester with glycerol |
247-668-1 26402-26-6 |
6.1.2 Long-term toxicity to fish | 29/07/2024 |
| Reaction mass of dodecyl 2-hydroxypropanoate and tetradecyl 2-hydroxypropanoate |
954-518-5 - |
6.1.2 Long-term toxicity to fish | 29/07/2024 |
| Sodium chlorite |
231-836-6 7758-19-2 |
6.1.2 Long-term toxicity to fish 7.6.2 Genetic toxicity in vivo |
28/06/2024 |
| Tetramethylammonium chloride |
200-880-8 75-57-0 |
6.1.2 Long-term toxicity to fish||Note: testing proposed with tetramethylammonium hydroxide | N,N,N-trimethylmethanaminium hydroxide (EC no. 200-882-9) 7.8.2 Developmental toxicity / teratogenicity |
29/07/2024 |
| Tetramethylammonium hydroxide |
200-882-9 75-59-2 |
7.8.2 Developmental toxicity / teratogenicity||Note: testing proposed with Tetramethyl ammonium chloride (EC no. 200-880-8) |
28/06/2024 |
| Zinc bis[bis(tetrapropylenephenyl)] bis(hydrogen dithiophosphate) |
234-277-6 11059-65-7 |
6.1.2 Long-term toxicity to fish |
29/07/2024 |
The ECHA’s consultation process ensures that additional testing for registered chemicals is transparently assessed. Feedback helps refine safety assessments and update testing protocols. Registrants must perform these tests and revise their safety data, ensuring chemical safety and fostering industry sustainability.
