In accordance with REACH regulations, before conducting tests under Annex IX and X (for registration volumes of 100-1000 tons per year and over 1000 tons per year), registrants must submit a testing proposal (TP). After a consultation period, ECHA will finalize the testing requirements based on feedback and the characteristics of the substance.
In April 2024, the European Chemicals Agency (ECHA) announced 22 new substance testing proposals and invited the public to submit their comments by April 22.
ECHA’s public consultation on substance testing proposals is a transparent process to determine if additional testing is needed for chemical registration dossiers to ensure safety. This process gathers input from various stakeholders to improve chemical safety assessments. After the consultation period, ECHA will adjust the testing requirements based on the feedback. Registrants must then conduct the specified tests, submit the results, and update their safety documentation to ensure safe use and promote industry sustainability.
| Name | EC Num. / CAS Num. | Hazard endpoint for which vertebrate testing was proposed | Deadline for submitting information |
| 1,3-bis(isocyanatomethyl)benzene |
222-852-4/ 3634-83-1 |
6.1.2 Long-term toxicity to fish | 22/04/2024 |
| 2,5-Furandione, dihydro-, mono-C15-20-alkenyl derivs. |
272-221-2/ 68784-12-3 |
6.1.2 Long-term toxicity to fish | 22/04/2024 |
| 2-[(2-methoxy-4-nitrophenyl)azo]-N-(2-methoxyphenyl)-3-oxobutyramide |
228-768-4/ 6358-31-2 |
7.5.2 Repeated dose toxicity: inhalation | 22/04/2024 |
| 3-[(5-cyano-6-hydroxy-1,4-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)diazenyl]phenyl benzoate | 953-951-7/- | 7.6.2 Genetic toxicity in vivo | 22/04/2024 |
| 4,4'-methylenebis[N,N-bis(2,3-epoxypropyl)aniline] |
249-204-3/ 28768-32-3 |
6.1.2 Long-term toxicity to fish | 27/05/2024 |
| 4-methylcyclohexanone |
209-665-3/ 589-92-4 |
6.1.2 Long-term toxicity to fish |
22/04/2024 |
| [3-(2,3-epoxypropoxy)propyl]trimethoxysilane |
219-784-2/ 2530-83-8 |
6.1.2 Long-term toxicity to fish |
22/04/2024 |
| Benzyldimethylamine |
203-149-1/ 103-83-3 |
6.1.2 Long-term toxicity to fish | 22/04/2024 |
| Bis(4-methylbenzoyl)peroxide |
407-950-9/ 895-85-2 |
6.1.2 Long-term toxicity to fish||Note: testing proposed with p-toluic acid (EC no. 202-803-3) or with bis(4-methylbenzoyl) peroxide (EC no. 407-905-9) | 22/04/2024 |
| Calcium 4-chloro-2-(5-hydroxy-3-methyl-1-(3-sulfonatophenyl)pyrazol-4-ylazo)-5-methylbenzenesulfonate |
403-530-4/ 129423-54-7 |
7.8.2 Developmental toxicity / teratogenicity | 22/04/2024 |
| Copper(I, II) sulfite |
884-197-6/ 15293-86-4 |
7.6.2 Genetic toxicity in vivo||Note: testing proposed with copper(I,II) sulfite dihydrate (CAS No. 13814-81-8) | 22/04/2024 |
| Dibromomethane |
200-824-2/ 74-95-3 |
7.6.2 Genetic toxicity in vivo | 27/05/2024 |
| Diethyl succinate |
204-612-0/ 123-25-1 |
7.5.1 Repeated dose toxicity: oral |
27/05/2024 27/05/2024 |
| Ethylbenzene |
202-849-4/ 100-41-4 |
6.1.2 Long-term toxicity to fish |
22/04/2024 |
| Manganate(1-), glycinato-N,O)[sulfato(2-)-O]-, hydrogen |
838-538-0/ 52139-31-8 |
7.6.2 Genetic toxicity in vivo |
27/05/2024 |
| Methyl benzoate |
202-259-7/ 93-58-3 |
6.1.2 Long-term toxicity to fish |
22/04/2024 |
| N,N,N',N'-tetramethyl-2,2'-oxybis(ethylamine) |
221-220-5/ 3033-62-3 |
7.8.1 Toxicity to reproduction |
22/04/2024 22/04/2024 |
| N-(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)-3-hydroxy-4-[[2-methoxy-5-[(phenylamino)carbonyl]phenyl]azo]naphthalene-2-carboxamide |
235-425-2/ 12225-06-8 |
7.5.2 Repeated dose toxicity: inhalation |
22/04/2024 22/04/2024 |
| N-(2-(dimethylamino)ethoxy)ethyl)-N-methyl-1,3-propanediamine |
470-720-1/ 189253-72-3 |
7.5.1 Repeated dose toxicity: oral |
27/05/2024 27/05/2024 |
| Polyhydroxy-N,N-polyalkylbenzene-polycarboxamide |
- |
7.5.1 Repeated dose toxicity: oral |
27/05/2024 27/05/2024 |
| Triisobutyl phosphate |
204-798-3/ 126-71-6 |
6.1.2 Long-term toxicity to fish |
27/05/2024 |
| Tris(p-isocyanatophenyl) thiophosphate |
223-981-9/ 4151-51-3 |
6.1.2 Long-term toxicity to fish |
22/04/2024 |
