Canada: 4 Substances Identified as Harmful in the Draft Assessment for the Substituted Phenols Group | Inventory Overview - APCIS | Asia-Pacific Chemical Inventory Search | Exsiting Chemical Inventory Search | Regulated Chemical Search | Prohibited and Restricted Chemical Search

In January 13, 2024, the Government of Canada released a draft risk assessment of 15 substances under the Canadian Environmental Protection Act (CEPA). The Government of Canada is now seeking for a 60-day public comments ending on March 13, 2024.

Based on all available lines of evidence presented in this draft assessment, there is a risk of harm to the environment from CAS RNs 118-82-1, 128-37-0, 36443-68-2, and 61788-44-1. Details of these 15 substituted substances are listed in the following table:

Substance Group	CAS RNs.	Substance Name	Result
Substituted Phenols Group	85-60-9	Phenol, 4,4'-butylidenebis[2-(1,1-dimethylethyl)-5-methyl-	Harmless
	96-69-5	Phenol, 4,4'-thiobis[2-(1,1-dimethylethyl)-5-methyl-	Harmless
	96-76-4	Phenol, 2,4-bis(1,1-dimethylethyl)-	Harmless
	98-54-4	Phenol, 4-(1,1-dimethylethyl)-	Harmless
	118-82-1	Phenol, 4,4'-methylenebis[2,6-bis(1,1-dimethylethyl)-	Harmful
	128-37-0	Phenol, 2,6-bis(1,1-dimethylethyl)-4-methyl-	Harmful
	128-39-2	Phenol, 2,6-bis(1,1-dimethylethyl)-	Harmless
	1843-03-4	Phenol, 4,4',4''-(1-methyl-1-propanyl- 3-ylidene)tris[2-(1,1-dimethylethyl)-5-methyl -	Harmless
	2082-79-3	Benzenepropanoic acid, 3,5-bis(1,1-dimethylethyl)-4-hydroxy-, octadecyl ester	Harmless
	4221-80-1	Benzoic acid, 3,5-bis(1,1-dimethylethyl)-4-hydroxy-, 2,4-bis(1,1-dimethylethyl)phenyl ester	Harmless
	6386-38-5	Benzenepropanoic acid, 3,5-bis(1,1-dimethylethyl)-4-hydroxy-, methyl ester	Harmless
	35958-30-6	Phenol, 2,2'-ethylidenebis[4,6-bis(1,1-dimethylethyl)-	Harmless
	36443-68-2	Benzenepropanoic acid, 3-(1,1-dimethylethyl)-4-hydroxy-5-methyl-, 1,2-ethanediylbis(oxy-2,1-ethanediyl) ester	Harmful
	41484-35-9	Benzenepropanoic acid, 3,5-bis(1,1-dimethylethyl)-4-hydroxy-, thiodi-2,1-ethanediyl ester	Harmless
	61788-44-1	Phenol, styrenated	Harmful

Draft Assessment Conclusion and Recommendation

The draft assessment proposes that CAS RNs 118-82-1 and 61788-44-1 meet the criteria for persistence and bioaccumulation, as defined in the Persistence and Bioaccumulation Regulations under CEPA. The proposed risk management objective for these two substances is to prevent and minimize releases of the substance to the aquatic environment to the greatest extent practicable.

The draft assessment proposes that CAS RNs 128-37-0 and 36443-68-2 meet the criteria for persistence but not bioaccumulation, according to the Persistence and Bioaccumulation Regulations. The proposed risk management objective for these two substances is to limit concentrations of the substances released from industrial formulation facilities to water, to levels that are protective of the aquatic environment.

Canada proposes to recommend that CAS RNs 118-82-1 and 61788-44-1 be added to Part 1 of Schedule 1 of CEPA; and CAS RNs 128-37-0 and 36443-68-2 be added to Part 2 of Schedule 1 of CEPA.

If the recommendation is adopted, risk assessment instrument must be proposed within 24 months from the date on which the Ministers recommended that the substances be added to Schedule of CEPA.

For CAS RNs 128-37-0 and 36443-68-2, release limits will be specified to limit releases of these substances from industrial formulation facilities to the aquatic environment. For CAS RNs 118-82-1 and 61788-44-1, regulatory or mandatory initiatives shall be considered such as: regulations on prohibit the manufacture, use, sale, offer for sale or import of the substance or products containing the substances; release limit shall be set.

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